Taking Equelle for Perimenopause Support

July 02, 2021.

Perimenopause is a transitional phase in a woman’s life that is accompanied by some new and intense symptoms. Many women liken perimenopause to “PMS on steroids.” Of course, every woman’s experience is different, but there are common trends in symptoms, including hot flashes, poor sleep, mood swings, and vaginal discomfort. Wouldn’t it be nice if there was one supplement that could alleviate, or at least improve, all of these symptoms? Well, Equelle is one such supplement that claims to do the trick. Let’s take a look at what is in Equelle and what reviewers say about its effectiveness. 

Who makes Equelle?

Perhaps one of the first things that will stand out to you about this supplement is its beautiful packaging. Equelle is a product from the makers of the Nature Made supplement brand. However, it looks nothing like their other supplement. Indeed, it is pretty enough to sit on the bathroom or kitchen counter. 

Nature Made is a vitamin and supplement company that has been making products since 1971. They are approved by the USP (United States Pharmacopeia) and have also been rated as a #1 Pharmacist Recommended Brand by U.S. News. 

What makes Equelle different?

Aside from the beautiful packaging, Equelle is a non-prescriptive dietary supplement the contains naturally derived S-equol. Sometimes referred to as Equelle Hot Flash Relief, this compound has a similar structure to estrogen, which means it may mimic estrogen in the body. Estrogen levels start to decrease when you are in menopause, which is why many women struggle with estrogen-related symptoms. 

Clinical trials of Equelle found that the S-equol helped improve symptoms because it makes the body think there is more estrogen than there actually is once you are in this life stage. 

Equelle Ingredients

Aside from S-equol, Equelle contains a small amount of soy, but the amount is significantly less than you would find in a single serving of common soy-based foods (per the Equelle website).  

Other inactive ingredients include cellulose gel, calcium phosphate, stearic acid, sorbitol, silicon dioxide, sodium silicate, croscarmellose sodium, and organic coating (tapioca, sunflower lecithin, palm oil, and guar gum).

Women taking Equelle find hot flash relief in as early as 4 weeks with regular use. By 8-12 weeks, participants reached optimal effectiveness. 

Equelle Side Effects

Even though S-equol mimics estrogen, it has not been shown to increase thyroid hormones or sex hormones like estrogen in the body. However, it does report that it may cause mild gastrointestinal upset. Like any supplement, if you do have an adverse reaction, it is important to discontinue using it and consult your doctor. 


Equelle Reviews

You can buy Equelle from the brand’s website and even sign up for a subscription. Or, you can purchase from larger retailers like Amazon, CVS, and Walmart. Indeed, that is where we get a lot of reviews for these products. 

Equelle has a little over 200 reviews on Amazon and receives an average of 4 stars. Positive reviews say that it works, especially in relieving hot flashes. Usually, if women leave a positive review, they are overwhelmingly in favor of these supplements. 

Negative reviews say that the supplements did not work or they were too expensive. In addition, a few select reviewers said they had trouble either swallowing the supplements or had an upset stomach with use. 

Find ther supplement product reviews from our community

Key Take-Aways on Equelle

Equelle is made by a well-known supplement brand and seems to be an appealing option for women in menopause. However, like any supplement, there is always the risk that it may either be ineffective or cause an adverse reaction. Also, the inclusion of a small amount of soy may be problematic for some women.

If you are struggling with hot flashes, it is best to consult your doctor first to see what recommendation may be best for you. Every person has their own unique medical history and profile, so it is best to get an individualized plan with your doctor to help you thrive during this phase. 

Disclaimer: This is not medical advice, does not take the place of medical advice from your physician, and is not intended to treat or cure any disease. Patients should see a qualified medical provider for assessment and treatment.

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Julia Walker
perry expert Julia (RN, BSN, BA) is a registered nurse based in Colorado. Julia's nursing background in women’s health has ranged from neonatal and postpartum care to labor and delivery, to outpatient gynecological medicine for both adolescent and adult populations. She specializes in helping women optimize their health during perimenopause and beyond.

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